Soubor:Mitochondrial OMM and matrix in MEF DRP1-KO CCCP.png
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Mitochondrial_OMM_and_matrix_in_MEF_DRP1-KO_CCCP.png (295 × 296 pixelů, velikost souboru: 110 KB, MIME typ: image/png)
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English: Fluorescent microscopy image of the mitochondria of a MEF cell in which the gene DRP1 has been knocked out. Even though the cell has been treated with carbonyl cyanide m-chlorophenyl hydrazone (CCCP) for 30 min, which would normally induce mitochondrial fragmentation via excessive mitochondrial fission, the lack of DRP1 prevents this effect and the mitochondria remain tubular. The image is an overlay of two images: the outer mitochondrial membrane (stained via TOMM20 and shown in red) and the mitochondrial matrix (stained via HSP60 and shown in green). Scale bar equivalent to 10 µm. |
| Datum | |
| Zdroj | Böhler et al. (2018) |
| Autor | Böhler P, Stuhldreier F, Anand R, Kondadi AK, Schlütermann D, Berleth N, Deitersen J, Wallot-Hieke N, Wu W, Frank M, Niemann H, Wesbuer E, Barbian A, Luyten T, Parys JB, Weidtkamp-Peters S, Borchardt A, Reichert AS, Peña-Blanco A, García-Sáez AJ, Itskanov S, van der Bliek AM, Proksch P, Wesselborg S, Stork B. (2018). "The mycotoxin phomoxanthone A disturbs the form and function of the inner mitochondrial membrane". Cell Death & Disease 9 (3): e286. DOI:10.1038/s41419-018-0312-8. |
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  Tento soubor podléhá licenci Creative Commons Uveďte autora 4.0 International.
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| Datum a čas | Náhled | Rozměry | Uživatel | Komentář | |
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| současná | 21. 2. 2018, 14:18 | | 295 × 296 (110 KB) | Shinryuu | {{Information |Description={{en|{{w|Fluorescent microscopy}} image of the {{w|mitochondria}} of a {{w|Mouse embryonic fibroblast|MEF}} cell in which the gene ''{{w|DRP1}}'' has been {{w|Gene knockout|knocked out}}. Even though the cell has been treated with {{w|Carbonyl cyanide m-chlorophenyl hydrazone|carbonyl cyanide ''m''-chlorophenyl hydrazone}} (CCCP) for 30 min, which would normally induce mitochondrial fragmentation via excessive {{w|mitochondrial fission}}, the lack of DRP1 prevents this effect and the mitochondria remain tubular. The image is an overlay of two images: the {{w|outer mitochondrial membrane}} (stained via {{w|TOMM20}} and shown in red) and the {{w|mitochondrial matrix}} (stained via {{w|HSP60}} and shown in green). Scale bar equivalent to 10 µm.}} |Source=[https://www.nature.com/articles/s41419-018-0312-8 Böhler et al. (2018)] |Date={{Date|2018|02|19}} |Author={{cite journal | authors = Böhler P, Stuhldreier F, Anand R, Kondadi AK, Schlütermann D, Berleth N, D... |
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